Trichostatin A
Information
- Drug Name
- Trichostatin A
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| uveal melanoma | BAP1 MUTATION BAP1 MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 22038994 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Somatic and germline BAP1 mutations are associated... | BAP1 | BAP1 MUTATION BAP1 MUTATION | Sensitivity | true | CIViC Evidence | detail |
| Butyrate as well as trichostatin A inhibited the c... | HDAC9 | HDAC9 EXPRESSION | Sensitivity | true | MMMP | detail |
| Sodium butyrate and trichostatin induced cell deat... | HDAC9 | HDAC9 EXPRESSION | Sensitivity | true | MMMP | detail |
| TSA is a HDAC inhibitor | PRAME | PRAME UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03838926 | Unknown status | Phase 1 | Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies | September 27, 2018 | September 2020 |